Following her studies at the University of Bristol and the Architecture Association in London, Louisa Hutton co-founded sauerbruch hutton in 1989 in London with Matthias Sauerbruch. Since 1993, the office has been based in Berlin.

Louisa has made significant contributions to the field of architecture through her role as a Commissioner for CABE (Commission for Architecture and the Built Environment) in the UK, her participation in the inaugural Steering Committee for Germany's Bundesstiftung Baukultur, and her work as a juror for the Schelling Architecture Awards. In addition to architectural practice, Louisa has taught at the Architectural Association and has served as a Visiting Professor at both the University of Virginia and Harvard Graduate School of Design.

Louisa is an Honorary Fellow of both the American Institute of Architects (AIA) and the Royal Institute of the Architects of Ireland (RIAI). In 2014, she was elected a Royal Academician, and in 2015, she was appointed an Officer of the Order of the British Empire (OBE) for her services to architecture.